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As the manufacturers of these nicotinamide vape products assert that nicotinamide is the main active ingredient but also claim to have pharmacological activity at nAChRs, the FDA can alternatively categorize these products as a drug and regulate them under the Federal Food, Drug, and Cosmetic Act (FDCA)

Maryland is the most striking recent example

And sure, heavy smokers might notice a slight uptick, but its like putting a postage stamp on a sinking ship and calling it good as new

More specifically, studies have shown that, in the presence of THC, compounds like CBD can potentially work as an antagonist of CB1 receptors [6] the main target for THC